Thursday, 9 May 2013

Peyronie's Disease Studies

The main PD studies page is here. The below studies are also relevant but more often than not relate to aspects of penile health not specifically linked to peyronie's disease treatments:

Testosterone deficiency - Peyronie's disease link 

An interesting study was posted in June highlighting low levels in testosterone in those with peyronie's disease. As this is a pilot study it's hard to know if this is a matter of causation or correlation, or for that matter if the results can be replicated.

In addition to other approaches to dealing with peyronie's, it may well be worth getting your testosterone levels checked. If they are low, the doctor may well suggest testosterone injections. If you wish to raise your levels naturally, then I recommend the supplement Tongkat Ali.


Not a new study, but an example of how the PAV cocktail (Pentoxifylline, L-Arginine and Viagra) helped in cases of priapism where the likely outcome was corporal fibrosis. Of course, it's unlikely to translate perfectly to peyronie's disease which is still not well understood, but it's a good starting point. View the study here.]

Decorin in the rat model

It's worth remembering that lots of drugs work well on the rat model of peyronie's disease and yet are often not as promising in human subjects. Still, it's good to know that work continues to find new effective treatments for men with peyronie's.

Peyronie's Disease Prevalence 

This new study touches on the difficulty there is in estimating how many men have peyronie's disease. I've heard various suggestions of how rare peyronie's is over the years, but it's not something that's easy to measure. Many men don't ever seek an official diagnosis due to fear or embarrassment. Add to that this study, which reveals that even those who do seek medical attention are often not initially diagnosed with PD. As such they frequently remain untreated at a time where they would best respond to treatment. The study goes some way to suggesting that peyronie's disease is, rather predictably very often underdiagnosed and undertreated.

Peyronie's Disease In Teenagers 

Peyronie's disease is often viewed to be a disease suffered solely by middle aged and elderly men. However, a significant number of young people likely also suffer from it. As we can see in this recent study high distress was experienced by a staggering 94% of patients between ages 15 and 19. There needs to be more appreciation in the medical community that young people can develop PD and that that peyronie's disease in young people brings about different challenges, both physically and mentally.

Testosterone deficiency 

This issue has been debated before in the peyronie's disease community. Whether low testosterone actually contributes to the development of PD, or instead contributes to the worsening of it, is unknown. Could it be that those with higher testosterone levels achieve more erections, which impede the development of scar tissue and/or stretch it as it forms?

Delicate tissue handling 

There is an increased rate of peyronie's disease amongst men following radical prostatectomy. It had been thought that cavernosal nerve damage was responsible for this, but this study hints at another potential contributing factor.

Association between peyronie's disease and dupuytren's disease 

A study linking dupuytren's contracture with peyronie's disease. This link has been known for many years, but it's a reasonably large study, so good to get what are likely fairly reliable percentages.
 ould take into account your erectile functioning when drawing conclusions about what treatment is right for you.

Traction therapy prior to penile prosthesis implantation 

An interesting study for men with shortened penis undergoing penile prosthesis implantation. Not only did traction device therapy allow these men to avoid length loss, it also promoted a small length gain in most of those taking part in the study. The duration that the traction device was worn for is much less than typically stated in most traction studies, but the results still show improvement. That's promising news.

Of course traction therapy isn't only useful for men with implants. It has been shown to reduce penile curvature in men with peyronie's disease. More info here.

Penetrative sexual activity in PD patients

A new study out this month from the Department of Urology, Manchester Royal Infirmary, Manchester, UK.

PDE5 Inhibitors and penile scar remodelling 

I haven't seen any previous reports specifically linking cialis with improvements in scarring. The study doesn't actually deal with penile curvature, so it's hard to know the real impact of the changes taking place. I had previously pondered whether the use of PDE5 inhibators in peyronie's disease extended beyond that of improved erectile functioning. The jury is still out on that one I guess, but this study does suggest that there might be more to its effectiveness than that.

Also of interest in this, and other peyronie's studies is "the length of time from onset to presentation". In this case it's 22 months. We need to get a firmer idea of during what time period oral treatments are effective and when they cease to be. Contrary to what opinion there currently is out there, I'm not convinced that we have anything like an answer to this question.

View the study here.

Circumcision in penile surgery

A new study suggests that circumcision shouldn't be viewed as routine part of penile surgery unless required. This is good news for those worried about being circumcised as part of a penile surgery procedure. On occasion, some surgeons have appeared to see circumcision as part of the natural process when undertaking surgery. Here we see that need not be the case. If you are set to undergo peyronie's surgery, you may wish to highlight this issue before hand.


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