Monday, 31 May 2010

Pycnogenol + L-Arginine ( Prelox )

I posted briefly some time ago about how Pycnogenol and L-Arginine in combination has been demonstrated to be useful in the treatment of moderate erectile dysfunction. A new UK study came out recently which supports this view. (Other Prelox studies [1] [2]).

Men with peyronie's disease often suffer from varying degrees of ED and as such for those with mild to moderate erectile dysfunction, this could be an over the counter option that they wish to explore instead of prescription route of Viagra, Cialis and Levitra. The study shows an increase in erection strength and plasma testosterone levels. The prelox treatment appears to be as effective (if not more so) the longer the therapy is used.

Patients of Dr Levine is the US have been known to take the PAV cocktail or a variation of it for a period of months (Pentoxifylline, L-Arginine and Viagra). Since L-arginine is already being taken, I wonder what impact adding Pycnogenol to the mix would be, if anything? There certainly appears to be a level of synergy between Pycnogenol and L-Arginine.

Tuesday, 18 May 2010

Vacuum Erection Device (VED) Study

Below is a link to the new vacuum erectile device (VED) study that I mentioned in the previous post.


The use of medical grade vacuum pumps has been a part of the peyronie's disease community for years now. Despite this fact, and many positive anecdotal reports, urologist in general have not embraced the VED as a viable treatment option.

This study, the first I have seen in relation to vacuum devices, goes some way to showing that it may well be a useful treatment option for those sufferers from peyronie's disease. The results are far from miraculous, and the sample is small, but curvature did improve in many patients to the point where surgery was not required. This is certainly a positive development in the lives of those men. The fact that pain improved too is a very promising finding, because both short (weeks to months) and in a minority cases very long term pain can, both physically and mentally, be a very difficult aspect of PD to deal with.

Let's hope that there are further VED studies undertaken in future, and that these too have positive outcomes. Perhaps a combined studies (involving Vacuum AND traction) or a combination of vacuum device and oral treatments should be carried out. Pentoxifylline for instance can sometimes soften scarring and calcified areas. This VED study write-up suggests that on soft scars VED therapy results may be more pronounced, therefore, it does start to make the case for combined therapy studies.

Friday, 14 May 2010

The role of vacuum pump therapy in Peyronie's disease

This new study is somewhat positive. It confirms what many have already known/suspected for quite some time: That VED Therapy can be useful in combating peyronie's disease. Like all peyronie's disease treatments out there, there is no magic bullet, but it's always pleasing to get confirmation that a treatment is useful, and that you're on the right track. In the peyronie's disease community many men have been saying for years now that VED useage improved their situation and it's good to see that echoed in this study.

From the study we see that a relatively short course of VED therapy can be useful to men suffering from peyronie's disease. In the best case scenario can improve the condition to the point where surgery may not be needed. For some men in the study VED therapy meant the difference between requiring surgery and not. For others, it helped to increase their penis size pre-surgery, which again is certainly a positive occurence.

It's of note that for three men in the study their condition worsened. I feel it would be alarmist to state that VED caused this, when it seems more likely that the treatment simply did not manage to reverse damage already occuring in an active stage of the disease. In many cases it takes 12-18 months for peyronie's disease to reach an end point (sometimes beyond that). It's even possible that their situation would've been worse still if they had not used VED, so in a sense even they may have seen an improvement. Of course, it's a very individual condition, so to state absolutes either way is never wise.

It would be of interest to gather further information about the specific protocol used in this study, as a way of contributing to the knowledge already out there. Many men currently use the Chris Spivey protocol. Also, in combining VED therapy with oral treatments, I would think that the chances of a positive outcome would rise further still. Perhaps the men above were taking oral treatments at the same time. At present I only have the study info stated here. I'll try to find out more.

Wednesday, 12 May 2010

Peyronie's Disease Research

To the Editor: Re. Peyronie’s Disease information found at:

Dear sir,

I found your website whilst looking for further information on Peyronie’s disease as part of a research study we are conducting to better understand the experiences, problems and issues faced on a daily basis by diagnosed Peyronie’s sufferers.

This research study will take the form of a 60-minute telephone interview with Peyronie’s patients who are willing to discuss the problems and issues faced since a diagnosis was made.

Eligible participants who go on to complete the interview will be offered £80 as a thank you for helping on this research. I would also like to stress that all information provided by participants in this research is treated in the strictest confidence, including names of participating individuals in accordance with the Data Protection Act. The research will be conducted under the Code of Conduct of the Market Research Society.

I would be grateful if you would post this information to any Peyronie’s patients who might be interested in helping out with this research. To help I have attached a flyer containing the full contact information for anyone interested in helping us with this research.

Many thanks in advance,

Kind regards,

Martin Evans

Direct Line: +44 (0)203 1300 640
Switchboard: +44 (0)203 1300 630
Fax Number: +44 (0)208 7882 042