Friday, 31 July 2009

Peyronie's Disease FAQs

This section is designed to answer any questions you may have relating to peyronie's disease.

Q) my husband last february noticed that his penis had curved massively seemed like over night. THis has made our sex life gone. 1st question is there anything he can do to help with the curviture. 2nd. it is extremely painful anything he can do for that 3rd. we have tryed vitamin E for about 2 months and he quit taking it how long does it take to show any effects. 4th should we try to of sex or will this make it worse i am looking for some answers to help him?

A) Sorry to hear about your husbands condition. The entire site is full of options aimed at improving peyronie's disease symptoms. He should definitely try pentoxifylline for an extended period of time (6 months +) and CoQ10 as recent reports have indicated that it's useful for pain. Adding Cialis/Viagra into the mis might be a good idea if he has ED.

Some form of sexual interaction is fine, unless he finds that it increases the pain, in which case I should avoid activies that make pain worse and centre in on treatments in the short term.

Q) My penis has been curved for as long as I can remember. Do I have peyronie's disease?
A) If your penis has been curved for your whole life, you certainly do not have peyronie's disease. Your condition in that instance would be described as a congenital curve. If you are able to have intercourse, then it's not something you should worry about. If your congenital curve is substantial and hinders intercourse, you may want to consider trying a traction device. If that doesn't help, surgery could be the option for you. You'd likely undergo a plication procedure. Go to your GP for further advice.

Q) I've tried various treatments and still my condition hasn't improved. What shall I do now?
Unfortunately not all men will benefit from the current oral or mechanical treatments. It's important to try to bring about a multipronged approach, because this maximises your chances of a positive outcome (traction + oral treatments, vacuum erection device and oral treatments etc). If your condition has been stable for six months and your curvature is significant, you may want to consider surgery.

Q) My doctor recommended that I take a "wait and see" approach, and suggested no treatment. Is he right to do this?

A) Peyronie's Disease is something that is ill understood by a great many people, even some of those whose job it is to know about these issues. Waiting for your condition to improve on its own is in my view not a sensible course of action. While no currently available treatment can claim to be a "magic bullet", available treatments have certainly helped many men, and what is to be lost from attempting to treat the condition ASAP? Nothing.

Q) My doctor tells me that Vitamin E is the only useful treatment for peyronie's disease. Is he correct?

A) Vitamin E used to be habitually given to peyronie's patients, but in studies it has not been shown to be particularly effective. This does not mean that you shouldn't include it in an oral regime, as there is little to lose, but it shouldn't be your only treatment. Ask your doctor about Pentoxifylline.

Q) Is there a cure for peyronie's disease?

A) At this time there is no cure as such for peyronie's disease. All treatments are designed to combat the condition and hopefully improve the eventual outcome. Traction is known to be able to reduce curvature. Trental has been demonstrated to reduce the size of plaque in some men, and so on. The more angles you attack this condition from, the greater hope there is of a satisfactory outcome.

Q)I have experienced sudden curvature, but no pain, so surely I cannot have peyronie's disease?

Although it is common, not all sufferers of peyronie's disease experience pain. Any change in the shape of your penis is of a concern and should be followed up on immediately.

Q)Why did you remove the google ads from the site? Some of the products looked useful.

They're designed to look that way by the advertisers. Unfortunately tonnes of 'miracle pill' type advertisements appeared and it's just a massive ripoff. I wrote a post about them here. I'd like nothing more than to be able to directly offer effective oral treatments on the site, but as most of those are prescription drugs that isn't possible.

Again, if you can help out by expanding on existing answers, or have a question you'd like answering contact the site.


Many of those with peyronie's disease suffer from ED (erectile dysfunction) as a result of their condition. It is of course healthy for all men to achieve erections on a regular basis, this is partly the reason why we have spontaneous erections, nocturnal erections and so on. L-Arginine is a precursor to NO (Nitric Oxide), which is required for erections to take place. Several studies have demonstrated an increase in the quality of erections from the use of L-Arginine.

L-Arginine is one of the cheapest supplements available and can be purchased from high street chains such as Holland & Barrett in the UK and numerous places abroad. For those looking for the best L-arginine supplement, San VasoFlow in a good option. It's popular in bodybuilding circles (provides a better "pump", more veined look etc) as well as fellow peyronie's patients where the benefit is increased bloodflow to the penis. Vasoflow is superior to many L-Arginine supplements due to its controlled release technology - so it stays in your system for longer. It is also coupled with L-Norvaline, which blocks the activity of arginase (promoting the conversion of arginine into nitric oxide). You could even combine Arginine with Pycnogenol , as studies have suggested powerful synergy between the two when it comes to treating ED.

This really is something that I would classify as a "must have", especially if you're in the active stage of the condition (as opposed to the chronic stage). L-Argine is sometimes used in combination with Pentoxifylline (Trental) and Viagra in what is known as the PAV cocktail. This treatment trio is recommended by some of the most respected peyronie's disease experts in the world (Dr Lue for instance).

Vitamin E

Vitamin E is a dilator of blood vessels and is known to prevent excessive scar tissue production when applied topically. I've personally had some success in using it to treat a scar caused by a burn to my skin, so I'm not a total vitamin E skeptic by any means. Years back it used to be the only treatment suggested for peyronie's disease sufferers, but this was mainly due to there being so few other available options, rather than a testament to the power of vitamin E.

Studies into Vitamin E have not particularly demonstrated it to be a powerful treatment for peyronie's disease. It is seen as a relatively safe though, and as such finds itself in the "does no harm, and may do some good" category. Some people swear by it, but in my view any improvement seen while taking vitamin E is more likely to be due to the natural course of peyronie's disease, or other treatments being taken alongside the vitamin. It perhaps is of some use when used as part of a multi-pronged strategy to combat the condition.

Should you wish to include vitamin E in a treatment program, I would advise you to purchase a full spectrum variety. Vitamin E consists of 8 fat soluble compounds. Many high street Vitamin E supplements only provide one of these, alpha-tocopherol, and so you may not be getting the maximum possible benefit. The full spec variety at least ensures that if this is a helpful treatment for you, you'll receive the maximum benefit from it.


Out of the many treatments suggested to peyronie's disease sufferers, curcumin is rarely mentioned. This is a shame as it has shown great promise in a number of conditions relating to imflammation and plaque. Of course there can be many key differences in plaque formation in various tissues around the body, but there are also similarities, so it's an option that should be given careful coinsideration.

There are various prescription TGF-beta inhibitors used to battle peyronie's (pentoxifylline, tamoxifen, etc) but curcumin is one of the only natural inhibitors of TGF-beta that I can think of. As peyronie's plaques contain a high level of TGF-Beta (which is a characteristic of a number of fibrotic diseases) there is good sense to combining a prescription route with a more natural and readily available course of treatment. In my view curcumin fits the bill.

The good news is that curcumin appears to be non toxic in high doses. The bad news however is that it has low bio-availability. As such there has been a trend towards finding ways to increase the effectiveness of curcumin. Many supplement companies mix it with bioperine (black pepper's active ingredient) as this makes the curcumin more readily available to the body. I would advise against taking any bioperine products if you're taking prescription medications though, as it is known to increase the bioavailability of certain substances while decreasing others. This makes it somewhat unpredictable.

Perhaps a safer way to consume curcumin and improve absorption is to dissolve it within warm oil. My personal oil of choice is extra virgin coconut oil. I heat the oil, then dissolve three or four curcumin capsules into it. Curcumin readily dissolves into oil and so this is the route I'd recommend for those wishing to try out this particular treatment to combat peyronie's disease. Other options include dissolving it into hot water (perhaps into tea) and taking supplements (Quercetin and Genistein) that inhibit the enzymes which can destroy curcumin.